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Seventy-five publications were included (Supplementary Figure 1), published between 1991 and September 2009 inclusive. Nearly three-quarters (55, 73%) were published between 2002 and September 2009 inclusive. There was no book focusing on PTA. Publications used many different terms to refer to PTA. 1 Table 2 describes further characteristics of the included publications.

Table 2.

Characteristics of publications included in this systematic review

Publications were assigned more than one content type where appropriate.

Discussion of whether there are PTA obligations.

Assessment of PTA regulations, guidelines and/or policies.

Publication that mentioned >12 narrow types of reasons that met the inclusion conditions.

Review of regulations, guidelines and/or policies regarding PTA.

Expression of mere opinion about whether there are PTA obligations.

Description of trial in which PTA was an issue.

Commentary on another publication included in this review.

Publication reporting empirical study, not necessarily of PTA.

Discussion of legal case in which PTA was an issue.

The 9 sections occurred in a total of three edited books.

The HIV/AIDS publications concerned AZT, ART or vaccine research.

See ‘Limitations’ section.

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Table 2.

Characteristics of publications included in this systematic review

Publications were assigned more than one content type where appropriate.

Discussion of whether there are PTA obligations.

Assessment of PTA regulations, guidelines and/or policies.

Publication that mentioned >12 narrow types of reasons that met the inclusion conditions.

Review of regulations, guidelines and/or policies regarding PTA.

Expression of mere opinion about whether there are PTA obligations.

Description of trial in which PTA was an issue.

Commentary on another publication included in this review.

Publication reporting empirical study, not necessarily of PTA.

Discussion of legal case in which PTA was an issue.

The 9 sections occurred in a total of three edited books.

The HIV/AIDS publications concerned AZT, ART or vaccine research.

See ‘Limitations’ section.

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The 75 publications together included 781 Reason Mentions, which we grouped under 36 broad and 235 narrow Types of Reason; when similar narrow types were merged to conduct the sensitivity analysis, there were 202 narrow Types of Reason ( Table 1 ). To generalize over the broad Types of Reason, reasons were based on considerations of morality, legality, interests and incentives, and/or practicality. Moral reasons belonged to two overlapping families: based on justice, or the roles of and relationships between stake-holders in research. Reasons classed under legality included reasons claiming that guidelines do (or do not) require ensuring PTA.

Despite the lack of large RCTs, there is sufficient evidence that dual-chamber cardiac pacing should be considered to reduce syncopal recurrences in patients affected by dominant cardioinhibitory CSS.

Two variables are well known to hamper the efficacy of pacing therapy in CSS: the mixed forms 93 , 98 (see also great deals sale online cheap enjoy Vans Men’s Ua Sk8Hi Reissue Lite HiTop Sneakers Canvas Larkspur/True Wh visa payment exclusive online TLI5L
section 5) and the association with positivity of tilt testing. Patients who have positive tilt tests have a three-fold greater probability of syncope recurrence after dual chamber pacing than those with negative tilt tests 293 , 295 ; thus, when tilt testing is positive, caution must be recommended over pacemaker implantation.

Effectiveness of pacing in patients with tilt-induced VVS has been studied in five multicentre RCTs. 296–300 When combining the results of these trials, 318 patients were evaluated; syncope recurred in 21% of the paced patients and in 44% of unpaced patients ( P < 0.001). A meta-analysis of all studies suggested a non-significant 17% reduction in syncope from the double-blind studies, and an 84% reduction in the studies where the control group did not receive a pacemaker. 301 In general, pacing was ineffective in trials that enrolled patients without an asystolic tilt response. 299 , 300 All of these studies have limitations, and a direct comparison is somewhat difficult because of important differences in study design, largely focused on patient selection. Overall, in typical vasovagal populations, pacing seems to have marginal efficacy.

The rationale for the efficacy of cardiac pacing is that the cardioinhibitory reflex is dominant in some patients, as there is no role for pacing in the preventing vasodilatation and hypotension. In a substudy of the ISSUE-3 trial, 302 an asystolic response during tilt testing predicted a similar asystolic form during spontaneous ILR-documented syncope, with a positive predictive value of 86%. In the tilt subgroup of the SUP 2 study, 292 among 38 patients with dominant cardioinhibitory reflex (with a mean asystolic pause of 22 ± 16 s) the estimated rates of syncope recurrence with pacing were 3% at 1 year, 17% at 2 years, and 23% at 3 years; these figures were significantly lower than the corresponding rates observed in untreated controls, and were similar to those observed in patients with CSS or with ECG-documented asystole. In a recent multicentre crossover RCT performed in 46 patients aged >40 years, affected by severely recurrent (>5 episodes during life) cardioinhibitory VVS, 303 during 24-month follow-up, syncope recurred in 4 (9%) patients treated with a dual-chamber pacemaker with closed-loop stimulation compared with 21 (46%) patients who had received a sham pacemaker programmed off ( P =0.0001).

Email Permutator spreadsheetbuilt by Rob Ousbey from Distilled is an impressive alternative.

These tools will get you a list of possible email addresses in seconds. Now you need one more tool which will check these suggestions: Sneaky Steve Jerome Mens Trainers outlet footlocker pictures from china free shipping quSIob
for Chrome (ex. Rapportive ). Install it now if you have not yet.

Now click “Compose” button in your Gmail and paste all the email permutations into the “To” field. Then move the cursor over the email address one by one and observe.

Gmail will show you if the email address is associated with a Google+ account, while the LinkedIn Sales Navigatorextension will reveal if this email address belongs to a LinkedIn profile (you must have a Linkedin account).

tip
If both Sales Navigator and Gmail remain silent, you can run another check by searching for the exact match of your best guess on Google to see if it was mentioned anywhere on the Web.

I don’t recommend relying on email verification services because they are often wrong.

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In reality, this email address does not exist. Unfortunately.

Now you might already be thinking that there’s a problem with this tip.

And if so, you are (kind of) right!

Googleuses the “@” symbol for social tags. And if you put “@ahrefs.com” (exact match search) in Google, you won’t find any email addresses.

But don’t forget that Google is not the only search engine!

I discovered this hack not so long ago: you can use Bing search instead.

Use exact match search for “@domainname.com,” and Bing will reveal email addresses related to this domain if they are publicly available.

As you can see, this little-known trick does work.

Sidenote.

Did you know that a user’s email address is always visible on LinkedIn for your direct connections?

Check one of your connection’s profiles, and their email address will be there for you to grab in the ‘Contact Info’ section.

Sidenote.

You can also export all your LinkedIn connections to a single file on your computer.

Here’s the official manual from LinkedIn:

You will then get a CSV file. And your connections’ email addresses will all be there.

That’s handy if you have a VA collecting email addresses for you. Just send the exported file over to your VA .

And here goes a warning message for everyone—don’t blindly connect with everyone on LinkedIn. You risk leaking your personal email address into improper hands!!!

I’ve seen plenty of contact pages where people say that the best way to reach them is to drop them a message on Twitter.

But generally the message you want to send is more than 280 characters long, so you’d prefer an email address.

If that’s the case, don’t hesitate to find that person on Twitter and ask for their email address.

You can give access to your clients via a private link so that they too can give feedback. And each team member on a particular project will be kept up to date on the version, as well as the comments and feedback that was left by both colleagues and clients.

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to share their creative work, GoVisually is built for small businesses and freelancers.

Clients and collaborators can make recommendations and give feedback without having to log into the system. And if you’re wondering, you can have an unlimited number of collaborators.

GoVisually lets you work on multiple projects, design files along with your team members and clients all from one place.

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At Time Doctor, we live in Google Docs. For a remote company of over 60 employees, we have found that Google Docs is the easiest way to collaborate, share, edit, and eventually publish documents of all kinds.

Google Docs allows us to create blog posts (like this one), spreadsheets, and presentations. It’s all for free, which is a blessing for startups and small businesses located in various parts of the globe.

This is Microsoft’s free version of its original Office suite of tools. You get the core of Office: Excel, PowerPoint, Word, and Onenote. When you combine it with Outlook.com , you essentially get the Office Home and Student suite.

There are certain limitations on the features that you get for free, however. For instance, if you wish to add a references section such as a table of contents and add citations, you will need to upgrade to the paid version.

There are also some font and formatting limitations as well. But, if you’re looking for basic documentation and editing tools, the free version will suit your needs just fine.

From its website: “Etherpad is a highly customizable Open Source online editor providing collaborative editing in really real-time.”

You can write articles, press releases, and to-do lists, with colleagues and clients all working and editing the same document in real time. And because it is open source, Etherpad is free to download.

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provides you with a set of project collaboration tools which helps the team members involved in the project to come together, plan, collaborate and get work done faster.

It helps you create project workspaces that will enable you to collaborate with teams in various geographical locations. You can give feedback, discuss projects in forums, and share a project calendar to increase productivity among team members.

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